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Melissa J Spencer Selected Research

Limb-girdle muscular dystrophy type 2H

5/2012Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H.
10/2011The common missense mutation D489N in TRIM32 causing limb girdle muscular dystrophy 2H leads to loss of the mutated protein in knock-in mice resulting in a Trim32-null phenotype.
11/2005Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin.

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Melissa J Spencer Research Topics

Disease

12Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
11/2021 - 10/2002
11Muscular Dystrophies (Muscular Dystrophy)
11/2021 - 08/2003
10Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy)
01/2020 - 10/2005
8Limb-girdle muscular dystrophy type 2A
09/2011 - 10/2003
3Atrophy
01/2018 - 08/2005
3Inflammation (Inflammations)
01/2016 - 10/2014
3Limb-girdle muscular dystrophy type 2H
05/2012 - 11/2005
2Muscular Diseases (Myopathy)
11/2021 - 04/2009
1Hypertrophy
01/2020
1Neoplasms (Cancer)
01/2019
1Colonic Neoplasms (Colon Cancer)
01/2019
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2019
1Disease Progression
01/2016
1Malignant Hyperthermia
12/2012
1Bardet-Biedl Syndrome (Syndrome, Bardet-Biedl)
10/2011
1Autolysis
09/2011
1Mitochondrial Diseases (Mitochondrial Disease)
09/2009
1Fibrosis (Cirrhosis)
06/2009
1Schizophrenia (Dementia Praecox)
05/2006
1Hermanski-Pudlak Syndrome (Hermansky-Pudlak Syndrome)
05/2006
1Distal Myopathies (Distal Muscular Dystrophy)
10/2005
1Myositis (Idiopathic Inflammatory Myopathies)
10/2005
1Hypercapnia
09/2003
1Muscular Atrophy (Muscle Atrophy)
12/2002
1Necrosis
10/2002

Drug/Important Bio-Agent (IBA)

11CalpainIBA
01/2018 - 10/2002
10DystrophinIBA
11/2021 - 10/2002
7Proteins (Proteins, Gene)FDA Link
12/2012 - 10/2003
6Peptide Hydrolases (Proteases)FDA Link
09/2011 - 10/2002
4OsteopontinIBA
10/2017 - 06/2009
4Cysteine Proteases (Cysteine Protease)IBA
09/2009 - 08/2005
3Carrier Proteins (Binding Protein)IBA
10/2017 - 05/2006
3Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
05/2015 - 04/2009
3ConnectinIBA
09/2011 - 07/2004
2CalciumIBA
11/2006 - 10/2002
1Muscle Proteins (Muscle Protein)IBA
11/2021
1UtrophinIBA
12/2020
1MyostatinIBA
01/2020
1AMP-Activated Protein KinasesIBA
01/2020
1Superoxide Dismutase-1IBA
01/2019
1PolymersIBA
01/2019
1Interleukin-12 (IL 12)IBA
01/2019
1Transforming Growth Factors (Transforming Growth Factor)IBA
10/2017
1Protein SIBA
03/2017
1Immunologic Factors (Immunomodulators)IBA
01/2016
1LuciferasesIBA
01/2015
1InterferonsIBA
10/2014
1Interleukin-10 (Interleukin 10)IBA
10/2014
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
10/2014
1Dantrolene (Dantrium)FDA LinkGeneric
12/2012
1Glycoproteins (Glycoprotein)IBA
12/2012
1Messenger RNA (mRNA)IBA
12/2012
1Tripartite Motif ProteinsIBA
10/2011
1Cysteine (L-Cysteine)FDA Link
09/2011
1Creatine Kinase (Creatine Phosphokinase)IBA
01/2011
1atalurenIBA
10/2009
1Long-Chain Acyl-CoA Dehydrogenase (Long-Chain-Acyl-Coenzyme A Dehydrogenase)IBA
09/2009
1Transforming Growth Factor beta (TGF-beta)IBA
06/2009
1dystrobrevinIBA
05/2006
1DysbindinIBA
05/2006
1Ligases (Synthetase)IBA
11/2005
1UbiquitinIBA
11/2005
1Myosins (Myosin)IBA
11/2005
1Ubiquitinated ProteinsIBA
08/2005
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2003
1calpastatinIBA
12/2002

Therapy/Procedure

3Therapeutics
01/2017 - 08/2003
1Precision Medicine
10/2009